Theaflavins Improve Memory Impairment and Depression-Like Behavior by Regulating Microglial Activation

PS147. Gunn rats show depression-like behavior and microglial activation in the hippocampus

Epigenetic Activation of ASCT2 in the Hippocampus Contributes to Depression-Like Behavior by Regulating D-Serine in Mice

The roles of D-serine in depression are raised concerned recently as an intrinsic co-agonist for the NMDA receptor. However, the mechanisms underlying its regulation are not fully elucidated. ASCT2 is a Na+-dependent D-serine transporter. We found that decreased D-serine and increased hippocampal ASCT2 levels correlated with chronic social defeat stress (CSDS) in mice. Lentivirus-mediated shRNA...

Improvement of depression-like behavior and memory impairment with the ethanol extract of Pleurotus eryngii in ovariectomized rats.

Ethanol extract of Pleurotus eryngii (DC.) QUÉL has estrogen-like activities that protect against bone loss caused by estrogen deficiency. In the present study, we investigated the effect of P. eryngii on depression-like behavior and memory impairment in ovariectomized (OVX) rats. Immobility time during a forced swimming test was significantly longer for OVX rats than for sham-operated rats. Th...

Comparative Analysis of Protein Tyrosine Phosphatases Regulating Microglial Activation

Protein tyrosine phosphatases (PTPs) are key regulatory factors in inflammatory signaling pathways. Although PTPs have been extensively studied, little is known about their role in neuroinflammation. In the present study, we examined the expression of 6 different PTPs (PTP1B, TC-PTP, SHP2, MEG2, LYP, and RPTPβ) and their role in glial activation and neuroinflammation. All PTPs were expressed in...

Effect of Methylmercury on Depression like Behavior in Rats: a Study Mitigated by Exogenous Vitamins

Depression is a heterogenous, multifaceted disorder with symptoms manifested at the psychological, behavioral and physiological level. Therefore, present study was designed as a model to analyze the long lasting effects of methylmercury chloride in male rats with a focus on depression like behavior. Male albino rats of Wistar strain were exposed orally to a dose of 2 mg/kg of methylmercury chlo...